Consideraciones sobre la experimentación in vivo en Argentina. Aplicación a un caso particular: implantes de titanio, titanio poroso y composite de titanio-hidroxiapatita.
AbstractWork with experimental animals to perform biocompatibility tests in vivo, requires compliance with various protocols. In addition, the use of animals for study has a number of ethical and legal implications that must be taken into account when planning experiences. In this paper we analyze the protocols that must be taken into account in Argentina for experimentation with laboratory animals. The results of in vivo implantation tests using Ti (TiD), porous titanium (TiP) and titanium-hydroxyapatite (TiHA) samples, obtained by the powder metallurgical process, in Wistar rats are also shown. The procedures developed for animal selection, surgical procedure and post-surgical control were adequate. Good adhesion of the bone to the surface of the implants could be verified and also a start of new bone growth in the pores of the porous implants.