Consideraciones sobre la experimentación in vivo en Argentina. Aplicación a un caso particular: implantes de titanio, titanio poroso y composite de titanio-hidroxiapatita.

  • M. Suarez Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba
  • A. Rivarola Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba
  • L. Grinschpun Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba
  • Carlos Oldani Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba
  • S. Maturana Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba
  • J. Bianchi Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba
  • J. Amietta Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba
  • L. Boezio Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba

Abstract

Work with experimental animals to perform biocompatibility tests in vivo, requires compliance with various protocols. In addition, the use of animals for study has a number of ethical and legal implications that must be taken into account when planning experiences. In this paper we analyze the protocols that must be taken into account in Argentina for experimentation with laboratory animals. The results of in vivo implantation tests using Ti (TiD), porous titanium (TiP) and titanium-hydroxyapatite (TiHA) samples, obtained by the powder metallurgical process, in Wistar rats are also shown. The procedures developed for animal selection, surgical procedure and post-surgical control were adequate. Good adhesion of the bone to the surface of the implants could be verified and also a start of new bone growth in the pores of the porous implants.
Published
2018-08-30
Section
Scientific articles