Electrocardiography in Wistar Rat Experimental Model: Analysis and Characterization
AbstractThe experimental model of Wistar rat (WR) is widely used by the scientific community for the evaluation of xenobiotics and environmental stressors. However, in spite of its great use, few publications have explicitly reported the differences between the parameters obtained from the ECG delineation and the different variables involved in the settings of a Wistar rat experiment. Variables such as supplied anesthesia, sex, age, weight, movement restriction and lead used influence the electrocardiographic parameters analyzed, such as RR, QT, PR intervals, P and QRS durations and peak amplitudes of P, Q, R, S, and T-waves. The first specific objective of this work is to organize the electrocardiographic parameters that have already been published by the scientific community according to their experimental setup. The second specific objective is to provide new parameters, such as the JTend and Tpe intervals, to the state of the art of Wistar rat ECG characterization. For this purpose, a database of 48 Wistar rats categorized by sex and age, measured in lead II, was processed and delineated.